Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.43 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8206485 | 0.90 | PIK3CA (0.52) | PIK3CAPIK3CDMTORALDH1A1POLB | |
| SCHEMBL11926139 | 0.89 | PIK3CA (0.47) | PIK3CAPIK3CDMTORMAPTMEN1 | |
| SCHEMBL8213164 | 0.87 | PIK3CA (0.55) | PIK3CAPIK3CDMTOR | |
| SCHEMBL8211441 | 0.87 | PIK3CA (0.54) | PIK3CAPIK3CDMTORPOLBKDR | |
| SCHEMBL8217106 | 0.85 | BDKRB1 (0.47) | PIK3CAPIK3CDMTORALDH1A1POLB | |
| SCHEMBL8213870 | 0.85 | PIK3CA (0.43) | PIK3CAPIK3CDMTORALDH1A1MAPT | |
| SCHEMBL8211493 | 0.85 | PIK3CA (0.50) | PIK3CAPIK3CDMTORALDH1A1POLB | |
| SCHEMBL11924820 | 0.84 | CA12 (0.45) | PIK3CAPIK3CDMTORALDH1A1MAPT | |
| SCHEMBL11925317 | 0.83 | KIF11 (0.42) | PIK3CAPIK3CDMTORALDH1A1MAPT | |
| SCHEMBL8215181 | 0.82 | NAMPT (0.42) | PIK3CAPIK3CDMTORALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |