Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.40 |
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CIT | O14578 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213870 | 0.89 | PIK3CA (0.43) | PIK3CAPIK3CDMTORMEN1ALDH1A1 | |
| SCHEMBL11925797 | 0.88 | PIK3CA (0.49) | KIF11PIK3CAPIK3CDMTORMEN1 | |
| SCHEMBL11924820 | 0.88 | CA12 (0.45) | PIK3CAPIK3CDMTORMEN1ALDH1A1 | |
| SCHEMBL8213164 | 0.87 | PIK3CA (0.55) | PIK3CAPIK3CDMTOR | |
| SCHEMBL8206190 | 0.86 | PIK3CD (0.43) | KIF11PIK3CAPIK3CDMTORMEN1 | |
| SCHEMBL11926139 | 0.85 | PIK3CA (0.47) | PIK3CAPIK3CDMTORMEN1MAPT | |
| SCHEMBL8205208 | 0.84 | PIK3CA (0.42) | PIK3CAPIK3CDMTOR | |
| SCHEMBL8206653 | 0.84 | KIF11 (0.42) | KIF11PIK3CAPIK3CDMTORMEN1 | |
| SCHEMBL11926872 | 0.84 | POLB (0.42) | PIK3CAPIK3CDMTORMEN1ALDH1A1 | |
| SCHEMBL8215177 | 0.83 | MTOR (0.37) | PIK3CAMTORGLAMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |