D-Glutamate

D-Glutamate

SCHEMBL8219044

CC(O)N[C@@H](CCC(N)=O)C(=O)O.NC(CCC(=O)O)C(=O)O

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.56
BLM P54132 1/20 0.56
PMP22 Q01453 1/20 0.56
KMT2A Q03164 1/20 0.56
GRM8 O00222 1/20 0.53
GRM6 O15303 1/20 0.53
GRIN2D O15399 1/20 0.53
GRIN3B O60391 1/20 0.53
GSR P00390 1/20 0.53
CYP1A2 P05177 1/20 0.53
GRIK1 P39086 1/20 0.53
GRM5 P41594 1/20 0.53
GRIA1 P42261 1/20 0.53
GRIA2 P42262 1/20 0.53
GRIA3 P42263 1/20 0.53
SLC1A3 P43003 1/20 0.53
SLC1A2 P43004 1/20 0.53
SLC1A1 P43005 1/20 0.53
GRIA4 P48058 1/20 0.53
GRIN1 Q05586 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3334377 0.87 KMT2A (0.45) ALOX15BLMPMP22KMT2AFOLH1
SCHEMBL1221387 0.87 KMT2A (0.45) ALOX15BLMPMP22KMT2AFOLH1
SCHEMBL4655466 0.84 FOLH1 (0.55) CYP1A2FOLH1NAALAD2RIMKLAGABRP
Alanyl Glutamine SCHEMBL31353025 0.81 NOD1 (0.61) ALOX15BLMPMP22KMT2AGRM8
Glutamine SCHEMBL9115599 0.81 ALOX15 (0.73) ALOX15BLMPMP22KMT2AGRM8
Glutamine SCHEMBL9115602 0.81 ALOX15 (0.73) ALOX15BLMPMP22KMT2AGRM8
Glutamine SCHEMBL1634485 0.80 PMP22 (0.86) ALOX15BLMPMP22KMT2AGRM8
Glutamine SCHEMBL352341 0.80 PMP22 (0.86) ALOX15BLMPMP22KMT2AGRM8
Glutamine SCHEMBL2443861 0.80 PMP22 (0.86) ALOX15BLMPMP22KMT2AGRM8
Glutamine SCHEMBL9276090 0.80 PMP22 (0.86) ALOX15BLMPMP22KMT2AGRM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0989864-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING ANTIBODY-ENZYME CONJUGATES IN COMBINATION WITH PRODRUGS THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON (GB) 2000-04-05 EP disclosed
WO-1998056425-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING ANTIBODY-ENZYME CONJUGATES IN COMBINATION WITH PRODRUGS THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON (GB) 1998-12-17 WO disclosed