Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.33 |
| ▸ | MTOR | P42345 | 8/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211538 | 0.83 | KIF11 (0.44) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL11924806 | 0.80 | PIK3CA (0.41) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8206742 | 0.79 | EPHX1 (0.45) | ALDH1A1CYP2C19KDR | |
| SCHEMBL11926868 | 0.77 | MEN1 (0.37) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL8212691 | 0.69 | MTOR (0.44) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL11926137 | 0.69 | FPR2 (0.46) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL8212549 | 0.69 | MTOR (0.48) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8213413 | 0.69 | PIK3CA (0.45) | ALDH1A1KDM4EPIK3CAMTORPIK3CG | |
| SCHEMBL8214220 | 0.68 | PIK3CA (0.48) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL8204669 | 0.68 | KMT2A (0.45) | MEN1ALDH1A1MAPTHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |