Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663194 | 0.80 | MEN1 (0.43) | LMNAKDM4EGAAHPGDRAB9A | |
| 2-Phenylthiazole SCHEMBL70646 | 0.77 | PDPK1 (1.00) | PDPK1CYP2A6LMNAKDM4EGAA | |
| SCHEMBL8290846 | 0.77 | ALOX15 (1.00) | ALOX15LMNAKDM4EERBB2GAA | |
| 2-Phenylthiazole SCHEMBL10519953 | 0.75 | PDPK1 (0.95) | PDPK1CYP2A6KDM4EPTGDR2KDR | |
| 2-Phenylthiazole SCHEMBL10667585 | 0.75 | PDPK1 (0.95) | PDPK1CYP2A6LMNAKDM4EGAA | |
| 2-Phenylthiazole SCHEMBL4939218 | 0.75 | PDPK1 (0.95) | PDPK1CYP2A6LMNAKDM4EGAA | |
| 2-Phenylthiazole SCHEMBL28319382 | 0.75 | PDPK1 (0.95) | PDPK1CYP2A6LMNAKDM4EGAA | |
| 2-Phenylthiazole SCHEMBL27882225 | 0.75 | PDPK1 (0.95) | PDPK1CYP2A6LMNAKDM4EGAA | |
| SCHEMBL5147639 | 0.74 | PDPK1 (0.91) | PDPK1CYP2A6PTGDR2KDRRAB9A | |
| SCHEMBL8214626 | 0.73 | PDPK1 (0.58) | PDPK1CYP2A6LMNAADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021960-A2 | TRIAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |