Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 4/20 | 0.48 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 6/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.40 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.40 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26666490 | 0.90 | PGR (0.56) | TNKSTNKS2PGRPDE7APKM | |
| SCHEMBL30701457 | 0.87 | PGR (0.58) | TNKSTNKS2PGRPDE7APKM | |
| SCHEMBL30701438 | 0.87 | PGR (0.58) | TNKSTNKS2PGRPDE7APKM | |
| SCHEMBL11641780 | 0.87 | PGR (0.58) | TNKSTNKS2PGRPDE7APKM | |
| SCHEMBL4715820 | 0.85 | PGR (0.59) | TNKSTNKS2PGRPDE7APKM | |
| SCHEMBL20955697 | 0.84 | PKM (0.53) | TNKSTNKS2PGRPDE7APKM | |
| SCHEMBL23778352 | 0.82 | CYP3A4 (0.43) | AKR1B1 | |
| SCHEMBL12437085 | 0.82 | TNKS (0.45) | TNKSTNKS2PGRPDE7APKM | |
| SCHEMBL30898646 | 0.81 | CMA1 (0.44) | TNKSTNKS2PGRCMA1AHR | |
| SCHEMBL23778308 | 0.81 | TNKS (0.50) | TNKSTNKS2PGRHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008055812-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |