Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22803653 | 0.81 | HSD17B10 (0.39) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| SCHEMBL21915154 | 0.79 | FFAR2 (0.49) | TSHRKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL13799349 | 0.78 | HPGD (0.52) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| SCHEMBL13177031 | 0.77 | PTGS2 (0.45) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| SCHEMBL16168604 | 0.77 | PTGS2 (0.45) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| SCHEMBL13176481 | 0.77 | PTGS2 (0.45) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| SCHEMBL20076744 | 0.75 | CXCR1 (0.56) | CYP2C9TSHRNFKB1HTR2APTGS2 | |
| Ammonia Solution, Strong SCHEMBL11508344 | 0.75 | PTGS2 (0.43) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| SCHEMBL4813777 | 0.75 | PTGS2 (0.43) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| SCHEMBL2163297 | 0.75 | HPGD (0.47) | ADRA2CCHRM2ADRA1ARGS12GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109201-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |