Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3519027 | 0.99 | ALOX15 (0.57) | ALOX15HTTUSP2ALDH1A1L3MBTL1 | |
| SCHEMBL8233041 | 0.83 | POLB (0.56) | ALOX15HTTALDH1A1LMNAGAA | |
| SCHEMBL8226106 | 0.79 | USP2 (0.54) | USP2ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL8234215 | 0.79 | MEN1 (0.60) | USP2ALDH1A1L3MBTL1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL3515589 | 0.78 | USP2 (0.53) | USP2ALDH1A1L3MBTL1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL3516384 | 0.78 | MEN1 (0.58) | USP2ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL4476411 | 0.77 | ALDH1A1 (0.71) | USP2ALDH1A1L3MBTL1PKMLMNA | |
| Hydrochloric Acid SCHEMBL3519020 | 0.75 | ALDH1A1 (0.69) | USP2ALDH1A1L3MBTL1PKMLMNA | |
| SCHEMBL17131811 | 0.75 | HTT (1.00) | ALOX15HTTALDH1A1MAPK14 | |
| SCHEMBL5717654 | 0.69 | POLB (0.74) | ALOX15HTTUSP2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029736-A1 | 2-SUBSTITUTED PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2010-02-04 | — | — | US | disclosed |
| WO-2008008551-A2 | 2-SUBSTITUTED PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029736-A1 | 2-SUBSTITUTED PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPSR1 | ALOX15 2411/4885HTT 301/4885USP2 1566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.