Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 15/20 | 0.67 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8224691 | 0.90 | CACNA1H (0.54) | CACNA1HNAMPT | |
| SCHEMBL8224871 | 0.89 | CACNA1H (0.62) | CACNA1HNAMPTCYP2C19FAAHCYP3A4 | |
| SCHEMBL8217859 | 0.86 | CACNA1H (0.61) | CACNA1HNAMPTCYP2C19 | |
| SCHEMBL8226405 | 0.85 | CACNA1H (0.50) | CACNA1HNAMPTCYP2C19FAAHCYP3A4 | |
| SCHEMBL8219197 | 0.84 | CACNA1H (0.78) | CACNA1H | |
| SCHEMBL8224684 | 0.80 | CACNA1H (1.00) | CACNA1H | |
| SCHEMBL8218859 | 0.80 | CACNA1H (1.00) | CACNA1HCYP2C19S1PR2CYP2D6 | |
| SCHEMBL13595981 | 0.78 | CACNA1H (0.84) | CACNA1H | |
| SCHEMBL8225905 | 0.78 | CACNA1H (0.78) | CACNA1H | |
| SCHEMBL13595938 | 0.77 | CACNA1H (0.84) | CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033456-A1 | SPIRO-CONDENSED AZETIDINE DERIVATIVES USEFUL IN TREATING PAIN, DIABETES AND DISORDERS OF LIPID METABILISM | SCHERING CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |