⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20262295 | 0.82 | — | — | |
| SCHEMBL7118503 | 0.82 | POLB (0.33) | — | |
| SCHEMBL6200283 | 0.82 | — | — | |
| SCHEMBL12973206 | 0.81 | ALDH1A1 (0.37) | — | |
| SCHEMBL23784196 | 0.80 | — | — | |
| SCHEMBL4287984 | 0.80 | ALDH1A1 (0.32) | — | |
| SCHEMBL11099311 | 0.80 | — | — | |
| SCHEMBL14399314 | 0.80 | CA2 (0.32) | — | |
| SCHEMBL14307355 | 0.80 | — | — | |
| SCHEMBL28304209 | 0.79 | HSP90AB1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3170807-A1 | NEW METHOD FOR SYNTHESIS OF FENFLURAMINE, OF ISOMERS THEROF AND/OR OF ANALOGS THEREOF, AND NEW COMPOSITIONS COMPRISING IT | Frau Pharma S.r.l. (IT) | 2017-05-24 | — | — | EP | disclosed |
| US-20090325208-A1 | Biosynthesis of Salinosporamide A and Analogs and Methods Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2009-12-31 | — | — | US | disclosed |
| WO-2008002600-A2 | BIOSYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS AND METHODS THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-01-03 | — | — | WO | disclosed |