Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AKT1S1 | Q96B36 | 3/20 | 0.35 |
| ▸ | MC4R | P32245 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 5/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | AKT2 | P31751 | 2/20 | 0.34 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738510 | 0.91 | PDE2A (0.38) | RPS6KB1MC4RHTR2AHTR2CHTR2B | |
| SCHEMBL2738553 | 0.91 | PDE2A (0.38) | RPS6KB1MC4RHTR2AHTR2CHTR2B | |
| SCHEMBL684792 | 0.85 | PAX8 (0.39) | MC4RPDE2ACDK2MAPK1AKT1 | |
| SCHEMBL684943 | 0.85 | PAX8 (0.39) | MC4RPDE2ACDK2MAPK1AKT1 | |
| SCHEMBL679705 | 0.84 | PDE2A (0.39) | AKT1S1MC4RPDE2ACDK2MAPK1 | |
| SCHEMBL680794 | 0.84 | PDE2A (0.39) | AKT1S1MC4RPDE2ACDK2MAPK1 | |
| SCHEMBL2738568 | 0.80 | MC4R (0.41) | MC4RHTR2AHTR2CHTR2BPDE2A | |
| SCHEMBL2738567 | 0.80 | MC4R (0.41) | MC4RHTR2AHTR2CHTR2BPDE2A | |
| SCHEMBL8229022 | 0.76 | IGF1R (0.44) | — | |
| SCHEMBL2738828 | 0.75 | PDE2A (0.45) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049501-B1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2008006040-A1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |