Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 16/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ESRRB | O95718 | 2/20 | 0.38 |
| ▸ | ESRRG | P62508 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738669 | 0.89 | IGF1R (0.44) | IGF1RMEN1KMT2AHSP90AA1NTSR1 | |
| SCHEMBL12294203 | 0.85 | IGF1R (0.43) | IGF1RMEN1KMT2AESRRBESRRG | |
| SCHEMBL12188348 | 0.82 | IGF1R (0.45) | IGF1RMEN1KMT2AHSP90AA1NTSR1 | |
| SCHEMBL680797 | 0.81 | IGF1R (0.44) | IGF1RMEN1KMT2AHSP90AA1NTSR1 | |
| SCHEMBL8225734 | 0.76 | RPS6KB1 (0.38) | — | |
| SCHEMBL8217371 | 0.76 | MC4R (0.48) | MEN1KMT2ANTSR1 | |
| SCHEMBL8226052 | 0.76 | MC4R (0.48) | MEN1KMT2ANTSR1 | |
| SCHEMBL12194515 | 0.73 | MC4R (0.46) | MEN1KMT2ANTSR1 | |
| SCHEMBL12294176 | 0.72 | ALDH1A1 (0.46) | MEN1KMT2ANTSR1 | |
| SCHEMBL8226410 | 0.70 | HRH3 (0.46) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006040-A1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |