Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738777 | 0.89 | TACR2 (0.47) | TACR2KDM4EALDH1A1LMNAPOLB | |
| SCHEMBL12292976 | 0.86 | HTR2A (0.35) | KCNA3OPRK1CYP2D6TERTHTR7 | |
| SCHEMBL2739268 | 0.83 | AKT1 (0.41) | TACR2KDM4EALDH1A1LMNAPOLB | |
| SCHEMBL2739269 | 0.83 | AKT1 (0.41) | TACR2KDM4EALDH1A1LMNAPOLB | |
| SCHEMBL12028792 | 0.82 | NTSR1 (0.45) | ALDH1A1ADRB2ADRB1ADRB3ADRA1D | |
| SCHEMBL8217369 | 0.82 | NTSR1 (0.45) | ALDH1A1ADRB2ADRB1ADRB3ADRA1D | |
| SCHEMBL2738773 | 0.82 | KCNA3 (0.38) | ALDH1A1KCNA3OPRK1CYP2D6HTR7 | |
| SCHEMBL2738529 | 0.77 | SLC18A3 (0.44) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL12188473 | 0.77 | TACR2 (0.49) | TACR2KDM4EALDH1A1LMNAPOLB | |
| SCHEMBL12391472 | 0.77 | TACR2 (0.49) | TACR2KDM4EALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2399909-A1 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as akt protein kinase inhibitors | Array Biopharma, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |
| WO-2008006040-A1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |