Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | USP14 | P54578 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8225848 | 0.86 | TACR2 (0.38) | HTR7KCNA3OPRK1CYP2D6TERT | |
| SCHEMBL2739268 | 0.86 | AKT1 (0.41) | GRM2OPRK1CYP2D6 | |
| SCHEMBL2739269 | 0.86 | AKT1 (0.41) | GRM2OPRK1CYP2D6 | |
| SCHEMBL10258343 | 0.86 | GRM2 (0.35) | GRM2KCNA3OPRM1HSD11B1TERT | |
| SCHEMBL2739260 | 0.84 | AKT1 (0.38) | — | |
| SCHEMBL2738649 | 0.84 | AKT1 (0.38) | — | |
| SCHEMBL2738773 | 0.82 | KCNA3 (0.38) | HTR2AHTR2CHTR7HTR6KCNA3 | |
| SCHEMBL17030316 | 0.82 | PDE2A (0.35) | HTR2AHTR2CGRM2KCNA3OPRM1 | |
| SCHEMBL2738791 | 0.81 | PDE2A (0.43) | — | |
| SCHEMBL2738777 | 0.79 | TACR2 (0.47) | HTR7OPRK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049501-B1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2011-09-14 | — | — | EP | disclosed |