Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320149 | 0.91 | SMN1; SMN2 (0.43) | PLAUHDAC1HDAC2HDAC3LMNA | |
| SCHEMBL7686880 | 0.87 | KMT2A (0.41) | PLAUSMN1; SMN2MAPTKDM4EMEN1 | |
| SCHEMBL6318265 | 0.79 | KMT2A (0.41) | SMN1; SMN2ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL7687225 | 0.75 | ALDH1A1 (0.42) | PLAULMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6310340 | 0.75 | LMNA (0.49) | LMNASMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL6316825 | 0.75 | HSD17B10 (0.48) | LMNASMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL6031270 | 0.72 | HSD17B10 (0.49) | SMN1; SMN2ALDH1A1MAPTNPSR1KDM4E | |
| SCHEMBL7516389 | 0.72 | ALDH1A1 (0.40) | HDAC1LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6313108 | 0.72 | MEN1 (0.38) | SMN1; SMN2ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL7525566 | 0.70 | SMN1; SMN2 (0.41) | LMNASMN1; SMN2ALDH1A1MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062204-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046244-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |