SCHEMBL82274

SCHEMBL82274

Clc1ccccc1C1(C2(c3ccccc3Cl)N=C(c3ccccc3)C(c3ccccc3)=N2)N=C(c2ccccc2)C(c2ccccc2)=N1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.40
CYP2A6 P11509 1/20 0.40
CRHBP P24387 1/20 0.37
CRHR2 Q13324 1/20 0.37
LMNA P02545 2/20 0.35
TSHR P16473 1/20 0.35
ALDH1A1 P00352 3/20 0.34
CYP1A2 P05177 2/20 0.33
HSD11B1 P28845 1/20 0.33
HPGD P15428 3/20 0.32
SMN1; SMN2 Q16637 3/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
TP53 P04637 1/20 0.32
ALPL P05186 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL491288 0.89 CYP1A2 (0.40) TAAR1CRHBPCRHR2LMNATSHR
SCHEMBL356036 0.87 CYP2A6 (0.36) TAAR1CYP2A6CRHBPCRHR2LMNA
SCHEMBL29403344 0.87 CYP2A6 (0.36) TAAR1CYP2A6CRHBPCRHR2LMNA
SCHEMBL11268438 0.86 ALDH1A1 (0.43) LMNAALDH1A1HPGDL3MBTL1NPC1
SCHEMBL491344 0.85 TAAR1 (0.36) TAAR1TSHRALDH1A1SMN1; SMN2MEN1
SCHEMBL5150338 0.85 ALDH1A1 (0.38) TAAR1CRHBPCRHR2LMNATSHR
SCHEMBL8830382 0.85 TAAR1 (0.36) TAAR1CRHBPCRHR2LMNATSHR
SCHEMBL1877506 0.85 TAAR1 (0.40) TAAR1ALDH1A1HPGDSMN1; SMN2MEN1
SCHEMBL29904508 0.85 TAAR1 (0.36) TAAR1TSHRALDH1A1SMN1; SMN2MEN1
SCHEMBL10874980 0.83 TAAR1 (0.31) TAAR1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2119 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8399176-B2 Photosensitive resin composition LG CHEM, LTD. (KR) 2013-03-19 US claimed
US-20100216073-A1 PHOTOSENSITIVE RESIN COMPOSITION LG CHEM, LTD. (KR) 2010-08-26 US claimed
EP-0520364-B1 Photopolymerizable composition FUJI PHOTO FILM CO LTD (JP) 1997-09-17 EP claimed
EP-0377321-B1 Photopolymerizable composition FUJI PHOTO FILM CO LTD (JP) 1995-03-22 EP claimed
US-5385807-A Photopolymerizable composition FUJI PHOTO FILM CO., LTD. (JP) 1995-01-31 US claimed
EP-0520364-A1 Photopolymerizable composition FUJI PHOTO FILM CO., LTD. (JP) 1992-12-30 EP claimed
US-5145760-A POSITIVE-WORKING PHOTOSENSITIVE ELECTROSTATIC MASTER WITH IMPROVED INVIRONMENTAL LATITUDE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-09-08 US claimed
EP-0243936-B1 PHOTOPOLYMER COLOR-PROOFING FILMS WITH IMPROVED WHITE LIGHT STABILITY E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-03-11 EP claimed
US-5049481-A Merocyanine compound FUJI PHOTO FILM CO., LTD. (JP) 1991-09-17 US claimed
US-4985470-A Three component photoinitiator system, printing plates, photoresists, inks, paints, adhesives MITSUBISHI KASEI CORPORATION (JP) 1991-01-15 US claimed
EP-0315116-A2 Photohardenable electrostatic master containing electron acceptor or donor E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-05-10 EP claimed
EP-0138187-B1 PHOTOPOLYMERIZABLE COMPOSITION MITSUBISHI KASEI CORPORATION (JP) 1989-01-11 EP claimed
EP-0243936-A2 Photopolymer color-proofing films with improved white light stability E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-11-04 EP claimed
US-4594310-A Photopolymerizable composition comprising tertiary aromatic amine and hexaarylbiimazole initiators MITSUBISHI CHEMICAL INDUSTRIES, LTD. (JP) 1986-06-10 US claimed
EP-0107792-B1 PHOTOPOLYMERIZABLE COMPOSITIONS MITSUBISHI KASEI CORPORATION (JP) 1985-12-27 EP claimed
EP-0138187-A2 Photopolymerizable composition MITSUBISHI KASEI CORPORATION (JP) 1985-04-24 EP claimed
EP-0107792-A1 Photopolymerizable compositions MITSUBISHI KASEI CORPORATION (JP) 1984-05-09 EP claimed
US-4271260-A POSITIVE IMAGES OBTAINED USING A SUPPORTED LAYER OF AN ALKALI-SOLUBLE POLYMERIC BINDER, A HEXAARYLBIIMIAZOLE, AND A CARBOXY-, CARBONYL-, OR CYANO-SUBSTITUTED DIHYDROPYRIDINE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-06-02 US claimed
US-4243741-A HEXAARYLBIIMIDAZOLE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-01-06 US claimed
US-4017313-A Photosensitive composition containing a leuco dye, a photosensitizer, an aromatic aldehyde and a secondary or tertiary amine and the use thereof in a direct-print process E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-04-12 US claimed