Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 10/20 | 0.54 |
| ▸ | DRD2 | P14416 | 8/20 | 0.54 |
| ▸ | DRD4 | P21917 | 6/20 | 0.54 |
| ▸ | DRD3 | P35462 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.50 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.50 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.50 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13777211 | 0.90 | GRM2 (0.64) | GRM2DRD2DRD4DRD3LMNA | |
| SCHEMBL4155805 | 0.87 | DRD2 (0.54) | GRM2DRD2DRD4DRD3LMNA | |
| SCHEMBL4154874 | 0.87 | GRM2 (0.50) | GRM2DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL4138733 | 0.87 | GRM2 (0.50) | GRM2DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL4149011 | 0.87 | GRM2 (0.51) | GRM2DRD2DRD4DRD3KDM4E | |
| SCHEMBL4152111 | 0.84 | GRM2 (0.58) | GRM2DRD2DRD4DRD3 | |
| SCHEMBL4142354 | 0.82 | LMNA (0.61) | GRM2DRD2DRD4DRD3LMNA | |
| SCHEMBL4157977 | 0.80 | GRM2 (0.61) | GRM2DRD2DRD4DRD3 | |
| SCHEMBL4162244 | 0.80 | GRM2 (0.53) | GRM2DRD2DRD4DRD3LMNA | |
| SCHEMBL4149712 | 0.80 | GRM2 (0.53) | GRM2DRD2DRD4DRD3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007115077-A2 | BICYCLIC BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |