Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 13/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8227499 | 0.91 | ELANE (0.64) | ELANECYP2C9ALDH1A1ADRB1HTR1A | |
| SCHEMBL8053053 | 0.91 | ELANE (0.64) | ELANECYP2C9ALDH1A1ADRB1HTR1A | |
| SCHEMBL10013423 | 0.87 | ELANE (0.49) | ELANECYP2C9LMNARECQLALDH1A1 | |
| SCHEMBL8055913 | 0.87 | ELANE (0.65) | ELANECYP2C9LMNARECQLALDH1A1 | |
| SCHEMBL10013425 | 0.85 | ELANE (0.68) | ELANECYP2C9LMNARECQLADRB1 | |
| SCHEMBL9914390 | 0.82 | ELANE (0.64) | ELANECYP2C9ALDH1A1ADRB1HTR1A | |
| SCHEMBL14899941 | 0.80 | ELANE (0.71) | ELANECYP2C9 | |
| SCHEMBL1134170 | 0.80 | ELANE (0.81) | ELANECYP2C9CYP3A4 | |
| SCHEMBL6295870 | 0.80 | ELANE (0.81) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8050837 | 0.80 | ELANE (0.79) | ELANECYP2C9LMNARECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060206-A1 | 3,4,6,7-TETRAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDINE-2,5-DIONES AND THEIR THERAPEUTIC USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |