Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17443453 | 0.85 | ABCC4 (0.49) | MAPTABCC4ALDH1A1LMNA | |
| SCHEMBL8222418 | 0.79 | USP2 (0.31) | USP2 | |
| SCHEMBL17443359 | 0.75 | CTSL (0.36) | MAPTABCC4ALDH1A1LMNAUSP2 | |
| SCHEMBL19154423 | 0.75 | CTSL (0.36) | MAPTABCC4ALDH1A1LMNAUSP2 | |
| SCHEMBL17443452 | 0.75 | CTSL (0.41) | MAPTABCC4ALDH1A1LMNAUSP2 | |
| SCHEMBL8227251 | 0.75 | MAPT (0.46) | MAPTABCC4ALDH1A1LMNAUSP2 | |
| SCHEMBL29254288 | 0.73 | MAPT (0.42) | MAPTABCC4ALDH1A1LMNAUSP2 | |
| SCHEMBL6562004 | 0.71 | MAPT (0.46) | MAPTABCC4ALDH1A1LMNAUSP2 | |
| SCHEMBL30712762 | 0.70 | PTGS1 (0.50) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL12325084 | 0.70 | USP2 (0.33) | MAPTALDH1A1LMNAUSP2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041159-B1 | MACROCYCLIC COMPOUNDS AS ANTIVIRAL AGENTS | ANGELETTI P IST RICHERCHE BIO (IT) | 2011-09-28 | — | — | EP | disclosed |
| WO-2007148135-A1 | MACROCYCLIC COMPOUNDS AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-12-27 | — | — | WO | disclosed |