SCHEMBL822781

SCHEMBL822781

C=CC(=O)OC12C(F)(F)C3(F)C(F)(F)C(F)(C1(F)F)C(F)(F)C(OC(=O)C=C)(C3(F)F)C2(F)F

nearest known ligand 0.30

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.30
ALDH1A1 P00352 3/20 0.30
TP53 P04637 2/20 0.30
HIF1A Q16665 2/20 0.30
CYP3A4 P08684 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL137442 0.98 TSHR (0.31) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL4323604 0.98 TSHR (0.31) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL4328621 0.91 TSHR (0.34) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL4320958 0.89
SCHEMBL4100640 0.89
SCHEMBL12977894 0.87
SCHEMBL4105874 0.85
SCHEMBL4333990 0.85
SCHEMBL14510336 0.83 TSHR (0.30) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL4105939 0.82 THRB (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2392972-B1 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus, and process for producing electrophotographic photosensitive member CANON KK (JP) 2016-07-20 EP disclosed
US-8865382-B2 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus, and process for producing electrophotographic photosensitive member CANON KABUSHIKI KAISHA (JP) 2014-10-21 US disclosed
US-8546052-B2 2013-10-01 US disclosed
US-8535862-B2 Electrophotographic photoreceptor, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2013-09-17 US disclosed
US-8535862-B2 Electrophotographic photoreceptor, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2013-09-17 US disclosed
US-8518618-B2 Electrophotographic photoconductor, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2013-08-27 US disclosed
US-8518618-B2 Electrophotographic photoconductor, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2013-08-27 US disclosed
US-20120009513-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2012-01-12 US disclosed
US-20120009513-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2012-01-12 US disclosed
US-20120008978-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2012-01-12 US disclosed
US-20070129566-A1 FLUOROADAMANTANE DERIVATIVE ASAHI GLASS COMPANY, LIMITED (JP) 2007-06-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070129566-A1 FLUOROADAMANTANE DERIVATIVE AFF1, AFF2, AFF4 TSHR 676/4885ALDH1A1 175/4885TP53 4546/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.