Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5029494 | 0.91 | STIM1 (0.51) | ADORA2ACYP3A4CYP2C19ALDH1A1KMT2A | |
| SCHEMBL8233603 | 0.84 | IL2 (0.38) | ALDH1A1KMT2AMAPK1STIM1ORAI1 | |
| SCHEMBL4724893 | 0.84 | ABL1 (0.44) | ADORA2ACYP3A4CYP2C19MCL1STIM1 | |
| SCHEMBL5027387 | 0.83 | IL2 (0.40) | ALDH1A1KMT2AMAPK1STIM1ORAI1 | |
| SCHEMBL4768209 | 0.82 | F2 (0.42) | ADORA2ACYP3A4CYP2C19MCL1STIM1 | |
| SCHEMBL5033790 | 0.80 | IL2 (0.48) | ALDH1A1KMT2ASTIM1ORAI1TYK2 | |
| SCHEMBL5030903 | 0.79 | ADORA2A (0.43) | ADORA2ACYP3A4CYP2C19ALDH1A1KMT2A | |
| SCHEMBL8236360 | 0.79 | LMNA (0.48) | ALDH1A1KMT2AMAPK1ORAI1MEN1 | |
| SCHEMBL2813632 | 0.77 | MCL1 (0.44) | ADORA2ACYP3A4CYP2C19KMT2AMCL1 | |
| SCHEMBL5030918 | 0.77 | LMNA (0.48) | ALDH1A1KMT2ASTIM1ORAI1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007087429-A2 | PHENYL AND PYRIDYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-08-02 | — | — | WO | disclosed |