Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.50 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.46 |
| ▸ | CDK4 | P11802 | 4/20 | 0.46 |
| ▸ | GSK3B | P49841 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8229238 | 0.94 | MAPK8 (0.52) | MKNK1PIK3C3MKNK2CDK4GSK3B | |
| SCHEMBL8235871 | 0.84 | CDK4 (0.58) | PIK3C3MKNK2CDK4GSK3BCDK2 | |
| SCHEMBL8233031 | 0.83 | PIK3C3 (0.54) | PIK3C3MKNK2CDK4GSK3BCDK2 | |
| SCHEMBL8227901 | 0.82 | CDK4 (0.57) | MKNK1CDK4GSK3BCDK2RET | |
| SCHEMBL5314566 | 0.82 | CDK4 (0.46) | MKNK1MKNK2CDK4GSK3BCDK2 | |
| SCHEMBL8235108 | 0.80 | CDK4 (0.51) | PIK3C3CDK4GSK3BCDK2RET | |
| SCHEMBL8229248 | 0.80 | CDK4 (0.50) | PIK3C3CDK4GSK3BCDK2MAPK8 | |
| SCHEMBL8234846 | 0.79 | CDK4 (0.44) | PIK3C3CDK4GSK3BCDK2RET | |
| SCHEMBL8233013 | 0.79 | CDK4 (0.44) | CDK4GSK3BCDK2RETMAPK1 | |
| SCHEMBL8233813 | 0.79 | IRAK1 (0.43) | MKNK1PIK3C3MKNK2CDK4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |