Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13213519 | 0.89 | HDAC1 (0.69) | ALDH1A1NPC1RAB9ASMN1; SMN2HDAC1 | |
| SCHEMBL8230787 | 0.85 | HDAC1 (0.64) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL21586315 | 0.79 | ALDH1A1 (0.74) | ALDH1A1NPC1RAB9AHTTHPGD | |
| SCHEMBL8272150 | 0.79 | HDAC1 (0.65) | HDAC1HDAC6HDAC9HDAC3HDAC2 | |
| SCHEMBL10809915 | 0.77 | MEN1 (0.86) | ALDH1A1NPC1RAB9AHTTHPGD | |
| SCHEMBL10923238 | 0.77 | ALDH1A1 (0.83) | ALDH1A1NPC1RAB9AHTTHPGD | |
| SCHEMBL24359677 | 0.77 | HDAC1 (0.78) | NPC1RAB9AHDAC1HDAC6HDAC9 | |
| SCHEMBL8227619 | 0.77 | HDAC1 (0.61) | SMN1; SMN2HDAC1HDAC6HDAC9HDAC3 | |
| SCHEMBL5999791 | 0.76 | HDAC1 (0.65) | ALDH1A1NPC1RAB9ASMN1; SMN2HDAC1 | |
| SCHEMBL24359341 | 0.76 | HDAC1 (0.77) | ALDH1A1NPC1RAB9AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653278-B2 | Isoform selective HDAC inhibitors | GEORGETOWN UNIVERSITY (US) | 2014-02-18 | — | — | US | disclosed |
| US-8653278-B2 | Isoform selective HDAC inhibitors | GEORGETOWN UNIVERSITY (US) | 2014-02-18 | — | — | US | disclosed |
| US-20100196502-A1 | Isoform Selective HDAC Inhibitors | GEORGETOWN UNIVERSITY (US) | 2010-08-05 | — | — | US | disclosed |
| US-20100196502-A1 | Isoform Selective HDAC Inhibitors | GEORGETOWN UNIVERSITY (US) | 2010-08-05 | — | — | US | disclosed |
| WO-2008019025-A2 | ISOFORM-SELECTIVE HDAC INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100196502-A1 | Isoform Selective HDAC Inhibitors | HDAC5, HDAC6, HDAC3 | ALDH1A1 1257/4885NPC1 1381/4885RAB9A 2546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.