Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8229145 | 0.85 | ALDH1A1 (0.60) | HDAC1HDAC6HDAC9HDAC3HDAC2 | |
| SCHEMBL13213519 | 0.85 | HDAC1 (0.69) | HDAC1HDAC6HDAC9HDAC3HDAC2 | |
| SCHEMBL8227619 | 0.83 | HDAC1 (0.61) | HDAC1HDAC6HDAC9HDAC3HDAC2 | |
| SCHEMBL8272150 | 0.82 | HDAC1 (0.65) | HDAC1HDAC6HDAC9HDAC3HDAC2 | |
| SCHEMBL8229932 | 0.82 | HDAC1 (0.58) | HDAC1HDAC6HDAC9HDAC3HDAC2 | |
| SCHEMBL1514632 | 0.80 | RAB9A (0.67) | HDAC1HDAC6HDAC9HDAC3HDAC2 | |
| SCHEMBL24359677 | 0.79 | HDAC1 (0.78) | HDAC1HDAC6HDAC9HDAC3HDAC2 | |
| SCHEMBL8272563 | 0.78 | HDAC1 (0.54) | HDAC1HDAC6HDAC9HDAC3HDAC2 | |
| SCHEMBL8227045 | 0.78 | MAPT (0.54) | HDAC1HDAC6HDAC9HDAC3HDAC2 | |
| SCHEMBL7256703 | 0.78 | RAB9A (0.70) | ALDH1A1MAPTHPGDSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653278-B2 | Isoform selective HDAC inhibitors | GEORGETOWN UNIVERSITY (US) | 2014-02-18 | — | — | US | disclosed |
| US-8653278-B2 | Isoform selective HDAC inhibitors | GEORGETOWN UNIVERSITY (US) | 2014-02-18 | — | — | US | disclosed |
| US-20100196502-A1 | Isoform Selective HDAC Inhibitors | GEORGETOWN UNIVERSITY (US) | 2010-08-05 | — | — | US | disclosed |
| US-20100196502-A1 | Isoform Selective HDAC Inhibitors | GEORGETOWN UNIVERSITY (US) | 2010-08-05 | — | — | US | disclosed |
| WO-2008019025-A2 | ISOFORM-SELECTIVE HDAC INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100196502-A1 | Isoform Selective HDAC Inhibitors | HDAC5, HDAC6, HDAC3 | HDAC1 4/4885HDAC6 2/4885HDAC9 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.