Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.41 |
| ▸ | CDK4 | P11802 | 7/20 | 0.41 |
| ▸ | CDK1 | P06493 | 6/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.41 |
| ▸ | CCND1 | P24385 | 5/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 11/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 11/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 10/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CCND3 | P30281 | 2/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8229255 | 0.71 | CDK2 (0.59) | CDK2CDK4CDK1CCNA2CCNB1 | |
| SCHEMBL5311762 | 0.71 | CDK1 (0.74) | CDK2CDK4CDK1CCNA2CCNB1 | |
| SCHEMBL8233754 | 0.70 | CDK1 (0.60) | CDK2CDK4CDK1CCNA2CCNB1 | |
| SCHEMBL8236156 | 0.70 | CDK2 (0.70) | CDK2CDK4CDK1CCNA2CCNB1 | |
| SCHEMBL8236618 | 0.70 | CDK2 (0.56) | CDK2CDK4CDK1CCNA2CCNB1 | |
| SCHEMBL8236067 | 0.69 | CDK2 (0.51) | CDK2CDK4CDK1CCNA2CCNB1 | |
| SCHEMBL8235683 | 0.69 | MAPK10 (0.48) | CDK2CDK4CDK1CCNA2CCNB1 | |
| SCHEMBL8236672 | 0.64 | CDK2 (0.55) | CDK2CDK4CDK1CCNA2CCNB1 | |
| SCHEMBL8233272 | 0.64 | MKNK1 (0.60) | CDK4GSK3B | |
| SCHEMBL8236601 | 0.63 | CDK4 (0.43) | CDK2CDK4CDK1CCNA2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |