Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.60 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8232828 | 0.77 | CDK4 (0.51) | CDK4 | |
| SCHEMBL13039331 | 0.77 | EIF2AK2 (0.60) | MKNK1CDK4GSK3BEIF2AK2DYRK1A | |
| SCHEMBL8235095 | 0.76 | NMT1 (0.52) | MKNK1CDK4 | |
| SCHEMBL18803524 | 0.75 | MKNK1 (1.00) | MKNK1CDK4GSK3BEIF2AK2FLT3 | |
| SCHEMBL8229255 | 0.74 | CDK2 (0.59) | CDK4GSK3B | |
| SCHEMBL8235029 | 0.74 | MAPK8 (0.49) | CDK4GSK3B | |
| SCHEMBL580579 | 0.72 | CDK4 (0.66) | MKNK1CDK4GSK3BEIF2AK2KMT2A | |
| SCHEMBL3652648 | 0.72 | MKNK1 (0.65) | MKNK1CDK4GSK3BEIF2AK2DYRK1A | |
| SCHEMBL8229254 | 0.72 | MAPK8 (0.51) | CDK4GSK3B | |
| SCHEMBL10323641 | 0.71 | FLT3 (0.58) | MKNK1CDK4GSK3BEIF2AK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |