Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 16/20 | 0.67 |
| ▸ | DRD4 | P21917 | 12/20 | 0.67 |
| ▸ | DRD3 | P35462 | 11/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | FAAH | O00519 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13484910 | 0.94 | DRD2 (0.67) | DRD2DRD4DRD3SIGMAR1ADRA1A | |
| SCHEMBL13484896 | 0.90 | DRD3 (0.58) | DRD2DRD4DRD3ADRA1AHTR1A | |
| SCHEMBL3976609 | 0.90 | DRD3 (0.60) | DRD2DRD4DRD3ADRA1AHTR1A | |
| SCHEMBL3981534 | 0.89 | MEN1 (0.58) | DRD2DRD4DRD3 | |
| SCHEMBL13484925 | 0.89 | DRD3 (0.66) | DRD2DRD4DRD3ADRA1AHTR1A | |
| SCHEMBL8233390 | 0.88 | DRD2 (0.65) | DRD2DRD4DRD3SIGMAR1ADRA1A | |
| SCHEMBL8229460 | 0.87 | DRD2 (0.55) | DRD2DRD4DRD3ADRA1AHTR1A | |
| SCHEMBL8231863 | 0.87 | DRD3 (0.60) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL3980521 | 0.87 | DRD3 (0.66) | DRD2DRD4DRD3ADRA1AHTR1A | |
| SCHEMBL13484916 | 0.87 | HTR1A (0.60) | DRD2DRD4DRD3ADRA1AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | disclosed |