Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 5/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 5/20 | 0.43 |
| ▸ | MMP13 | P45452 | 5/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.36 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10162842 | 0.93 | MMP13 (0.41) | CACNA1GCACNA1HCACNA1IMMP13ADAMTS4 | |
| SCHEMBL8228615 | 0.93 | MMP13 (0.50) | CACNA1GCACNA1HCACNA1IMMP13ADAMTS4 | |
| SCHEMBL8226242 | 0.93 | MAPK1 (0.41) | CACNA1GCACNA1HCACNA1IMMP13ADAMTS4 | |
| SCHEMBL8225958 | 0.92 | TP53 (0.44) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10162857 | 0.92 | MMP13 (0.39) | CACNA1GCACNA1HCACNA1IMMP13PDGFRA | |
| SCHEMBL10162855 | 0.92 | MMP13 (0.39) | CACNA1GCACNA1HCACNA1IMMP13PDGFRA | |
| SCHEMBL10210496 | 0.91 | MMP13 (0.43) | CACNA1GCACNA1HCACNA1IMMP13ADAMTS4 | |
| SCHEMBL10208196 | 0.91 | MMP13 (0.38) | CACNA1GCACNA1HCACNA1IMMP13PDGFRA | |
| SCHEMBL8228662 | 0.91 | MMP13 (0.39) | CACNA1GCACNA1HCACNA1IMMP13PDGFRA | |
| SCHEMBL8229567 | 0.91 | ROCK2 (0.42) | MMP13ADAMTS4MMP3MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |