Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8226281 | 0.92 | MMP13 (0.42) | MMP13ADAMTS4MMP3ALDH1A1HPGD | |
| SCHEMBL8226356 | 0.90 | MMP13 (0.40) | MMP13ADAMTS4MMP3KDM4EALDH1A1 | |
| SCHEMBL8226375 | 0.90 | HSD17B10 (0.45) | MMP13ADAMTS4MMP3KDM4EALDH1A1 | |
| SCHEMBL10163484 | 0.90 | MMP13 (0.43) | MMP13ADAMTS4MMP3KDM4EALDH1A1 | |
| SCHEMBL8226605 | 0.90 | MMP13 (0.43) | MMP13ADAMTS4MMP3KDM4EALDH1A1 | |
| SCHEMBL8225565 | 0.88 | TP53 (0.43) | MMP13ADAMTS4MMP3KMT2AMAPT | |
| SCHEMBL8221168 | 0.88 | MMP13 (0.43) | MMP13ADAMTS4MMP3KDM4EALDH1A1 | |
| SCHEMBL8226363 | 0.88 | MMP13 (0.41) | MMP13ADAMTS4MMP3KDM4EALDH1A1 | |
| SCHEMBL8229794 | 0.88 | MMP13 (0.43) | MMP13ADAMTS4MMP3KDM4EALDH1A1 | |
| SCHEMBL8225294 | 0.88 | ADAMTS4 (0.38) | MMP13ADAMTS4MMP3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |