Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.73 |
| ▸ | MMP9 | P14780 | 7/20 | 0.73 |
| ▸ | MMP12 | P39900 | 7/20 | 0.73 |
| ▸ | MMP14 | P50281 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6929207 | 0.96 | MMP2 (0.67) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL8228483 | 0.90 | MMP2 (0.61) | MMP2MMP9MMP12MMP14L3MBTL1 | |
| SCHEMBL8228240 | 0.87 | MMP2 (0.72) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL315140 | 0.85 | MMP2 (1.00) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL10049358 | 0.83 | MMP2 (0.66) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL8231456 | 0.83 | MMP2 (0.72) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL8228138 | 0.82 | MMP2 (0.59) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL10049377 | 0.82 | SMN1; SMN2 (0.52) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL315491 | 0.81 | MMP2 (1.00) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL315440 | 0.80 | MMP2 (0.92) | MMP2MMP9MMP12MMP14MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093386-B2 | Thioaryl substituted inhibitors of zinc proteases and their use | BRACCO IMAGING S.P.A (IT) | 2012-01-10 | — | — | US | disclosed |
| US-8093386-B2 | Thioaryl substituted inhibitors of zinc proteases and their use | BRACCO IMAGING S.P.A (IT) | 2012-01-10 | — | — | US | disclosed |
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | BRACCO IMAGING SPA (IT) | 2009-09-24 | — | — | US | disclosed |
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | BRACCO IMAGING SPA (IT) | 2009-09-24 | — | — | US | disclosed |
| WO-2008015139-A2 | INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE | BRACCO IMAGING SPA (IT) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | SERPINB1, ZFX, MMP2 | MMP2 3/4885MMP9 8/4885MMP12 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.