Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC1 | P19801 | 2/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 6/20 | 0.35 |
| ▸ | CA1 | P00915 | 6/20 | 0.35 |
| ▸ | CA2 | P00918 | 6/20 | 0.35 |
| ▸ | CA9 | Q16790 | 6/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8223054 | 0.77 | AOC1 (0.41) | AOC1AOC3IMPDH2GAAKDM4E | |
| SCHEMBL16326502 | 0.76 | CA12 (0.33) | IMPDH2TDP1CA12CA1CA2 | |
| SCHEMBL19225669 | 0.76 | IMPDH2 (0.36) | IMPDH2CA12CA1CA2CA9 | |
| SCHEMBL20777739 | 0.74 | — | — | |
| SCHEMBL16702153 | 0.73 | HASPIN (0.43) | AOC1AOC3IMPDH2GAAKDM4E | |
| SCHEMBL11023159 | 0.72 | — | — | |
| SCHEMBL31354791 | 0.72 | — | — | |
| SCHEMBL19225663 | 0.72 | IMPDH2 (0.36) | IMPDH2 | |
| SCHEMBL4169429 | 0.72 | AOC3 (0.44) | AOC1AOC3GAAKDM4EALDH1A1 | |
| SCHEMBL16712907 | 0.72 | AOC1 (0.44) | AOC1AOC3IMPDH2GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007144128-A1 | PYRROLIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-12-21 | — | — | WO | disclosed |