Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380643 | 0.86 | HPGD (0.53) | STK33HPGDSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL17590085 | 0.73 | MAOA (0.44) | HPGDSMN1; SMN2ALDH1A1RAB9AKDM4E | |
| SCHEMBL1245083 | 0.72 | HPGD (0.47) | STK33HPGDSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL8231854 | 0.72 | HDAC1 (0.39) | STK33HPGDSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL1244988 | 0.70 | NPC1 (0.51) | STK33HPGDSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL8229717 | 0.70 | AHR (0.40) | F2F10MAPK1 | |
| SCHEMBL303302 | 0.68 | MAOA (0.61) | HPGDSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL29860722 | 0.68 | MAOA (0.61) | HPGDSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL15580925 | 0.68 | MAOA (0.61) | HPGDSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL1245014 | 0.68 | KMT2A (0.51) | STK33HPGDSMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029586-B1 | ISOINDOLIN-1-ONE-, ISOINDOLIN-3-ONE- AND ISOINDOLIN-1,3-DIONE-DERIVATIVES AND USE THEREOF | BAYER SCHERING PHARMA AG (DE) | 2010-11-24 | — | — | EP | disclosed |
| WO-2007137790-A1 | ISOINDOLIN-1-ONE-, ISOINDOLIN-3-ONE- AND ISOINDOLIN-1,3-DIONE-DERIVATIVES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-12-06 | — | — | WO | disclosed |