Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | GFER | P55789 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | RAD52 | P43351 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8236174 | 0.77 | MAPT (0.55) | MAPTKDM4ESMN1; SMN2GFERGAA | |
| SCHEMBL6550226 | 0.73 | MAPT (0.61) | MAPTKDM4ESMN1; SMN2GFERGAA | |
| SCHEMBL4438019 | 0.70 | MAPT (0.62) | MAPTKDM4ESMN1; SMN2GFERGAA | |
| SCHEMBL6151797 | 0.70 | MAPT (0.62) | MAPTKDM4ESMN1; SMN2GFERGAA | |
| SCHEMBL1018073 | 0.70 | MAPT (0.61) | MAPTKDM4ESMN1; SMN2GFERGAA | |
| SCHEMBL943610 | 0.70 | MAPT (0.66) | MAPTKDM4ESMN1; SMN2GFERGAA | |
| SCHEMBL6698558 | 0.69 | MAPT (0.60) | MAPTKDM4ESMN1; SMN2GFERGAA | |
| SCHEMBL4499003 | 0.68 | KDM4E (0.58) | MAPTKDM4ESMN1; SMN2GFERGAA | |
| SCHEMBL158007 | 0.67 | MAPT (1.00) | MAPTKDM4ESMN1; SMN2GFERGAA | |
| SCHEMBL6152136 | 0.67 | MAPT (1.00) | MAPTKDM4ESMN1; SMN2GFERGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |