Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | GFER | P55789 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | RAD52 | P43351 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17194427 | 0.82 | MAPT (0.51) | MAPTGFERGAAKDM4ESMN1; SMN2 | |
| SCHEMBL1018073 | 0.82 | MAPT (0.61) | MAPTGFERGAAKDM4ESMN1; SMN2 | |
| SCHEMBL175992 | 0.81 | CHRNA7 (0.58) | MAPTKDM4ESMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4687789 | 0.80 | TMEM97 (0.42) | MAPTGFERGAAKDM4ESMN1; SMN2 | |
| SCHEMBL7423220 | 0.79 | OPRD1 (0.60) | MAPTGAASIGMAR1HTR7CYP1A2 | |
| SCHEMBL6550223 | 0.79 | KMT2A (0.51) | ALDH1A1HTTKMT2AMEN1NPC1 | |
| SCHEMBL3263264 | 0.79 | MAPT (0.43) | MAPTGFERGAAKDM4ESMN1; SMN2 | |
| SCHEMBL6698558 | 0.78 | MAPT (0.60) | MAPTGFERGAAKDM4ESMN1; SMN2 | |
| SCHEMBL23347931 | 0.78 | MAPT (0.77) | MAPTGFERGAAKDM4ESMN1; SMN2 | |
| SCHEMBL7043679 | 0.78 | MAPT (0.77) | MAPTGFERGAAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383753-A1 | PIPERAZINE-BENZAMIDE DERIVATIVES USEFUL AS APOB-100 AND/OR MTP INHIBITOR | GLAXO GROUP LIMITED (GB) | 2004-01-28 | — | — | EP | claimed |
| WO-2003047575-A1 | THERAPEUTIC BENZAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-06-12 | — | — | WO | claimed |
| WO-2002083658-A1 | PIPERAZINE-BENZAMIDE DERIVATIVES USEFUL AS APOB-100 AND/OR MTP INHIBITOR | GLAXO GROUP LIMITED (GB) | 2002-10-24 | — | — | WO | claimed |
| EP-1383753-A1 | PIPERAZINE-BENZAMIDE DERIVATIVES USEFUL AS APOB-100 AND/OR MTP INHIBITOR | GLAXO GROUP LIMITED (GB) | 2004-01-28 | — | — | EP | disclosed |
| WO-2003047575-A1 | THERAPEUTIC BENZAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003048121-A1 | THERAPEUTIC BENZAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-06-12 | — | — | WO | disclosed |
| WO-2002083658-A1 | PIPERAZINE-BENZAMIDE DERIVATIVES USEFUL AS APOB-100 AND/OR MTP INHIBITOR | GLAXO GROUP LIMITED (GB) | 2002-10-24 | — | — | WO | disclosed |