Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | GFER | P55789 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | RAD52 | P43351 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL943610 | 0.81 | MAPT (0.66) | MAPTGFERGAASMN1; SMN2KDM4E | |
| SCHEMBL1815259 | 0.78 | MAPT (0.62) | MAPTGFERGAASMN1; SMN2KDM4E | |
| SCHEMBL8230856 | 0.77 | MAPT (0.49) | MAPTGFERGAASMN1; SMN2KDM4E | |
| SCHEMBL4438019 | 0.75 | MAPT (0.62) | MAPTGFERGAASMN1; SMN2KDM4E | |
| SCHEMBL6151797 | 0.75 | MAPT (0.62) | MAPTGFERGAASMN1; SMN2KDM4E | |
| SCHEMBL5725588 | 0.74 | MAPT (0.61) | MAPTGFERGAASMN1; SMN2KDM4E | |
| SCHEMBL4499003 | 0.73 | KDM4E (0.58) | MAPTGFERGAASMN1; SMN2KDM4E | |
| SCHEMBL188931 | 0.72 | MAPT (0.54) | MAPTGFERGAASMN1; SMN2KDM4E | |
| SCHEMBL158007 | 0.72 | MAPT (1.00) | MAPTGFERGAASMN1; SMN2KDM4E | |
| SCHEMBL6152136 | 0.72 | MAPT (1.00) | MAPTGFERGAASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |