Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5478892 | 0.79 | MAPT (0.40) | NPC1RAB9AUSP30SMN1; SMN2TP53 | |
| SCHEMBL5482293 | 0.78 | P2RX7 (0.40) | NPC1RAB9AUSP30S1PR1SMN1; SMN2 | |
| SCHEMBL5491291 | 0.78 | CHRNB2 (0.39) | NPC1USP30CPT2CPT1ATP53 | |
| SCHEMBL5485357 | 0.77 | CHRNB2 (0.45) | USP30CPT2CPT1AALDH1A1HPGD | |
| SCHEMBL1544442 | 0.76 | KCNH2 (0.47) | NPC1RAB9ASMN1; SMN2TP53GRM5 | |
| SCHEMBL5485393 | 0.74 | USP30 (0.43) | NPC1RAB9AUSP30S1PR1SMN1; SMN2 | |
| SCHEMBL4327916 | 0.74 | KCNH2 (0.47) | NPC1RAB9ASMN1; SMN2TP53GRM5 | |
| SCHEMBL1544389 | 0.74 | CHRNB2 (0.44) | NPC1RAB9AUSP30CPT2CPT1A | |
| SCHEMBL1544334 | 0.72 | USP30 (0.47) | USP30S1PR1CPT2CPT1AGRM5 | |
| SCHEMBL4333880 | 0.72 | MAPT (0.36) | NPC1RAB9ASMN1; SMN2HSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007130824-A2 | FUSED HETEROCYLIC COMPOUNDS AND THEIR USE AS MGLUR5 MODULATORS | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |