Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | DGKA | P23743 | 1/20 | 0.37 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10001567 | 0.86 | TSHR (0.59) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL30977007 | 0.84 | TSHR (0.57) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL30977043 | 0.84 | TSHR (0.57) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL17784564 | 0.84 | TSHR (0.57) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL30977033 | 0.84 | TSHR (0.57) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL28133608 | 0.81 | TSHR (0.55) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL14718405 | 0.81 | TSHR (0.53) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL1973150 | 0.81 | TSHR (0.52) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL9480309 | 0.79 | TSHR (0.46) | TSHRHPGDALDH1A1CYP3A4THRB | |
| SCHEMBL17851221 | 0.79 | TSHR (0.62) | TSHRHPGDALDH1A1TP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110280912-A1 | DEGRADABLE POLYMER NANOSTRUCTURE MATERIALS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-11-17 | — | — | US | disclosed |
| WO-2011081659-A1 | DEGRADABLE POLYMER NANOSTRUCTURE MATERIALS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110280912-A1 | DEGRADABLE POLYMER NANOSTRUCTURE MATERIALS | BCAT1, PCBP1, TRIM4 | TSHR 4873/4885HPGD 3909/4885ALDH1A1 1806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.