Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21518299 | 0.82 | TSHR (0.54) | TSHRMEN1THRBHTTKMT2A | |
| SCHEMBL7600587 | 0.80 | — | — | |
| SCHEMBL9442174 | 0.75 | — | — | |
| SCHEMBL6883385 | 0.71 | TSHR (0.52) | TSHRMEN1THRBHTTKMT2A | |
| SCHEMBL9848721 | 0.71 | TSHR (0.46) | TSHRZDHHC20MEN1THRBHTT | |
| SCHEMBL30723488 | 0.70 | TSHR (0.32) | TSHRALDH1A1GAA | |
| Acetonitrile SCHEMBL17627828 | 0.70 | TSHR (0.55) | TSHRZDHHC20MEN1THRBHTT | |
| SCHEMBL28158590 | 0.70 | TSHR (0.62) | TSHRMEN1THRBHTTKMT2A | |
| SCHEMBL9162272 | 0.70 | TSHR (0.50) | TSHRMEN1THRBHTTKMT2A | |
| SCHEMBL19040804 | 0.70 | TSHR (0.50) | TSHRMEN1THRBHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084595-A2 | CARBOCYCLIC AND HETEROCYCLIC ARYLSULFONES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2007-07-26 | — | — | WO | disclosed |