Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GRK2 | P25098 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365487 | 0.79 | MAPT (0.74) | MAPTALDH1A1CHRNA7BCHEACHE | |
| SCHEMBL13595969 | 0.77 | SMN1; SMN2 (0.50) | TP53SMN1; SMN2MAPTTHRBLMNA | |
| SCHEMBL6560372 | 0.70 | GRK2 (0.48) | SMN1; SMN2MAPTTHRBALDH1A1GRK2 | |
| SCHEMBL4417239 | 0.70 | CHRM3 (0.54) | CHRNA7 | |
| Trapencaine SCHEMBL31345279 | 0.70 | FAAH (0.49) | THRBALDH1A1POLBFAAHACHE | |
| SCHEMBL2151177 | 0.69 | GRK2 (0.68) | SMN1; SMN2LMNAALDH1A1GRK2CASP6 | |
| SCHEMBL28263497 | 0.68 | GAA (0.53) | SMN1; SMN2MAPTLMNAALDH1A1GRK2 | |
| SCHEMBL12745630 | 0.67 | EPHX2 (0.49) | SMN1; SMN2MAPTLMNAALDH1A1GRK2 | |
| SCHEMBL515154 | 0.67 | GAA (0.62) | SMN1; SMN2MAPTLMNAALDH1A1POLB | |
| SCHEMBL17098885 | 0.66 | GRK2 (0.44) | TP53SMN1; SMN2MAPTALDH1A1GRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007100430-A2 | CYTISINE AND ACETYLCHOLINE ANALOGS AND METHODS OF TREATING MOOD DISORDERS | YALE UNIVERSITY (US) | 2007-09-07 | — | — | WO | disclosed |