SCHEMBL6560372

SCHEMBL6560372

O=C(Nc1cccc(Br)c1)OC1CCCC1=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRK2 P25098 1/20 0.48
CASP6 P55212 1/20 0.48
CASP8 Q14790 1/20 0.48
CTDSP1 Q9GZU7 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
FAAH O00519 2/20 0.44
MGLL Q99685 1/20 0.44
GRM5 P41594 1/20 0.44
KMT2A Q03164 3/20 0.43
MAPT P10636 3/20 0.43
GAA P10253 2/20 0.43
ALDH1A1 P00352 2/20 0.43
TRPV1 Q8NER1 1/20 0.43
MEN1 O00255 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
TGM2 P21980 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.41
THRB P10828 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6070016 0.79 CYP1A2 (0.63) GRK2CASP6CASP8CTDSP1TDP1
SCHEMBL8008669 0.75 GRK2 (0.61) GRK2CASP6CASP8CTDSP1TDP1
SCHEMBL28263497 0.72 GAA (0.53) GRK2CASP6CASP8CTDSP1TDP1
SCHEMBL13595969 0.72 SMN1; SMN2 (0.50) GRK2CASP6CASP8CTDSP1TDP1
SCHEMBL12745630 0.71 EPHX2 (0.49) GRK2CASP6CASP8CTDSP1TDP1
SCHEMBL7365487 0.71 MAPT (0.74) MAPTGAAALDH1A1
SCHEMBL515154 0.71 GAA (0.62) FAAHKMT2AMAPTGAAALDH1A1
SCHEMBL8233198 0.70 TP53 (0.55) GRK2CASP6CASP8CTDSP1TDP1
SCHEMBL515153 0.70 TGM2 (0.60) KMT2AGAAALDH1A1MEN1TGM2
SCHEMBL3926664 0.68 GRK2 (0.64) GRK2CASP6CASP8CTDSP1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1054869-B1 3,4-DIHYDROQUINOLINE DERIVATIVES AS NITROGEN MONOXIDE SYNTHASE (NOS) INHIBITORS SCHERING AG (DE) 2004-09-22 EP disclosed
EP-1115708-B1 AMINOALKYL-3,4-DIHYDROQUINOLINE DERIVATES AS NO-SYNTHASE INHIBITORS SCHERING AG (DE) 2004-04-14 EP disclosed
EP-1115708-A1 AMINOALKYL-3,4-DIHYDROQUINOLINE DERIVATES AS NO-SYNTHASE INHIBITORS Schering Aktiengesellschaft (DE) 2001-07-18 EP disclosed
EP-1054869-A1 3,4-DIHYDROQUINOLINE DERIVATIVES AS NITROGEN MONOXIDE SYNTHASE (NOS) INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 2000-11-29 EP disclosed
WO-2000017167-A1 AMINOALKYL-3,4-DIHYDROQUINOLINE DERIVATES AS NO-SYNTHASE INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 2000-03-30 WO disclosed
WO-1999041240-A1 3,4-DIHYDROQUINOLINE DERIVATIVES AS NITROGEN MONOXIDE SYNTHASE (NOS) INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 1999-08-19 WO disclosed