Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 3/20 | 0.44 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13919601 | 0.92 | ATM (0.49) | ATMAPPAKT1 | |
| SCHEMBL12336762 | 0.90 | ATM (0.60) | ATMAPPCYP3A4AKT1 | |
| SCHEMBL4900744 | 0.90 | ATM (0.60) | ATMAPPCYP3A4AKT1 | |
| SCHEMBL4898325 | 0.90 | ATM (0.60) | ATMAPPCYP3A4AKT1 | |
| SCHEMBL13162709 | 0.89 | ATM (0.51) | ATMALDH1A1APPAKT1 | |
| SCHEMBL2617222 | 0.88 | CTSS (0.53) | ATMAPPAKT1 | |
| SCHEMBL4728727 | 0.88 | ATM (0.50) | ATMCASP3APPPOLBAKT1 | |
| SCHEMBL25152858 | 0.87 | ATM (0.45) | ATMAPPCYP3A4AKT1 | |
| SCHEMBL29919429 | 0.87 | ATM (0.45) | ATMAPPCYP3A4AKT1 | |
| SCHEMBL21447184 | 0.86 | ATM (0.48) | ATMAPPPPARGPPARAAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |