Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 8/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592678 | 0.85 | AKT1 (0.46) | AKT1PIK3C3PPARGHPGDSAKT2 | |
| SCHEMBL8240638 | 0.84 | AKT1 (0.51) | AKT1PIK3C3AKT2AKT3 | |
| SCHEMBL8241464 | 0.84 | ATM (0.39) | AKT1PIK3C3MEN1POLBKMT2A | |
| SCHEMBL4583522 | 0.80 | AKT1 (0.41) | AKT1PIK3C3HPGDS | |
| SCHEMBL8242361 | 0.80 | AKT1 (0.71) | AKT1HPGDSAKT2AKT3 | |
| SCHEMBL8243099 | 0.80 | AKT1 (0.47) | AKT1PPARGHPGDS | |
| SCHEMBL8242925 | 0.79 | PIK3C3 (0.42) | AKT1PIK3C3MEN1POLBKMT2A | |
| SCHEMBL8240491 | 0.77 | PIK3C3 (0.38) | AKT1PIK3C3MEN1POLBKMT2A | |
| SCHEMBL8244308 | 0.77 | SCN9A (0.42) | AKT1 | |
| SCHEMBL4592495 | 0.76 | AKT1 (0.46) | AKT1PIK3C3PPARGHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |