Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 2/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583522 | 0.86 | AKT1 (0.41) | AKT1HPGDSPIK3C3KLKB1CYP2C19 | |
| SCHEMBL8233993 | 0.85 | AKT1 (0.45) | AKT1PPARGHPGDSPIK3C3AKT2 | |
| SCHEMBL8243099 | 0.83 | AKT1 (0.47) | AKT1PPARGHPGDS | |
| SCHEMBL4633196 | 0.77 | CYP2C19 (0.46) | PIK3C3CYP2C19 | |
| SCHEMBL4592495 | 0.74 | AKT1 (0.46) | AKT1PPARGPIK3C3KLKB1CYP2C19 | |
| SCHEMBL8233302 | 0.73 | AKT1 (0.63) | AKT1AKT2AKT3 | |
| SCHEMBL8241464 | 0.72 | ATM (0.39) | AKT1PIK3C3 | |
| SCHEMBL4584230 | 0.70 | AKT1 (0.48) | AKT1PIK3C3AKT2AKT3CYP2C19 | |
| SCHEMBL8240638 | 0.70 | AKT1 (0.51) | AKT1PIK3C3AKT2AKT3 | |
| SCHEMBL8242925 | 0.70 | PIK3C3 (0.42) | AKT1PIK3C3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |