Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.31 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646734 | 0.89 | MAPT (0.36) | PDE10ACYP3A4KDM4EALDH1A1STIM1 | |
| SCHEMBL11940271 | 0.89 | PTGS2 (0.38) | PDE10ACYP3A4RXRAHPGDSTIM1 | |
| SCHEMBL646474 | 0.86 | RXRA (0.39) | RXRAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL647042 | 0.84 | MAPT (0.38) | PDE10ACYP3A4KDM4EALDH1A1STIM1 | |
| SCHEMBL646334 | 0.80 | MAPT (0.36) | PDE10ACYP3A4KDM4EALDH1A1STIM1 | |
| SCHEMBL647141 | 0.78 | TSHR (0.38) | CYP3A4ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL646799 | 0.78 | NAMPT (0.37) | RXRAKDM4E | |
| SCHEMBL8228712 | 0.77 | MEN1 (0.39) | AOC3MEN1KMT2AHCRTR1 | |
| SCHEMBL648068 | 0.76 | MKNK1 (0.38) | CYP3A4KDM4EALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL646764 | 0.76 | ABL1 (0.42) | RXRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109362-A2 | BENZOIMIDAZOLYL-PARAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-09-27 | — | — | WO | disclosed |