Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8235132 | 0.92 | PIK3CD (0.46) | PIK3CDMAPK1PTGESSMN1; SMN2MAPT | |
| SCHEMBL8232417 | 0.87 | PTK2 (0.46) | PIK3CDMAPK1PTGESSMN1; SMN2MAPT | |
| SCHEMBL13170600 | 0.82 | DEGS1 (0.52) | NPC1SMN1; SMN2MAPTRAB9ADEGS1 | |
| SCHEMBL5034938 | 0.82 | PIK3CD (0.48) | PIK3CDNPC1GSK3BGSK3AGLA | |
| SCHEMBL8235267 | 0.82 | ABL1 (0.53) | — | |
| SCHEMBL15681778 | 0.81 | GSK3B (0.51) | PIK3CDNPC1GSK3BGSK3AGLA | |
| SCHEMBL13170688 | 0.80 | NPC1 (0.54) | NPC1MAPK1LMNASMN1; SMN2MAPT | |
| SCHEMBL13170834 | 0.80 | ABCB1 (0.44) | NPC1SMN1; SMN2MAPTPORCNNPSR1 | |
| SCHEMBL13170260 | 0.79 | MAPT (0.42) | NPC1LMNASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL13171494 | 0.79 | ALDH1A1 (0.40) | NPC1LMNASMN1; SMN2MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007087442-A2 | SUBSTITUTED BIARYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-08-02 | — | — | WO | disclosed |