SCHEMBL8235267

SCHEMBL8235267

COOCc1ccc(Cl)c(-c2ccc(NC(=O)C3CCCC3)nc2)c1

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 11/20 0.53
CDK9 P50750 3/20 0.43
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8234656 0.87 ABL1 (0.54) ABL1
SCHEMBL8232417 0.85 PTK2 (0.46) ABL1MEN1KMT2A
SCHEMBL8235132 0.83 PIK3CD (0.46) ABL1
SCHEMBL8234530 0.82 PIK3CD (0.48)
SCHEMBL5034800 0.81 MEN1 (0.50) ABL1CDK9MEN1KMT2A
SCHEMBL13170600 0.81 DEGS1 (0.52) MEN1KMT2A
SCHEMBL15681774 0.81 ABL1 (0.54) ABL1KMT2A
SCHEMBL5031483 0.81 MEN1 (0.52) ABL1CDK9MEN1KMT2A
SCHEMBL15681773 0.80 ABL1 (0.53) ABL1KMT2A
SCHEMBL5030684 0.79 ABL1 (0.49) ABL1CDK9MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007087442-A2 SUBSTITUTED BIARYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES SYNTA PHARMACEUTICALS CORP. (US) 2007-08-02 WO disclosed