Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4164752 | 0.82 | PDE10A (0.44) | PDE10ATAAR1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4165792 | 0.82 | PDE10A (0.44) | PDE10ATAAR1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4167893 | 0.76 | PDE10A (0.44) | PDE10ATAAR1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4155866 | 0.76 | PDE10A (0.44) | PDE10ATAAR1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8078229 | 0.72 | PDE10A (0.43) | PDE10A | |
| SCHEMBL8230235 | 0.69 | ADRA1D (0.43) | PDE10AEHMT2EHMT1 | |
| SCHEMBL4173265 | 0.69 | ADRA1D (0.46) | PDE10A | |
| SCHEMBL4778181 | 0.68 | KDR (0.40) | PDE10A | |
| SCHEMBL2949402 | 0.68 | TAAR1 (0.71) | TAAR1CYP3A4 | |
| SCHEMBL24391836 | 0.67 | HTR1A (0.41) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007100880-A1 | CINNOLINE AND QUINAZOLINE DERIVATES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-09-07 | — | — | WO | disclosed |