Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89867 | 0.93 | REN (0.42) | RENPOLBKMT2AMEN1TDP1 | |
| SCHEMBL89516 | 0.90 | REN (0.42) | RENPOLBCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL89127 | 0.88 | REN (0.41) | RENPOLBCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL89529 | 0.88 | TDP1 (0.43) | RENPOLBEPHX2KMT2AMEN1 | |
| SCHEMBL8235755 | 0.88 | REN (0.54) | REN | |
| SCHEMBL1911409 | 0.88 | REN (0.44) | RENPOLBCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL89822 | 0.88 | REN (0.44) | RENPOLBCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL90131 | 0.87 | REN (0.43) | RENPOLBCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL90013 | 0.87 | REN (0.48) | RENPOLBCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL10282943 | 0.87 | REN (0.43) | RENPOLBCYP1A2CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |