Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 12/20 | 0.65 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 2/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8230026 | 0.92 | PLAU (0.77) | PLAUTAS1R3TAS1R1TAS1R2KLKB1 | |
| SCHEMBL8235456 | 0.84 | PLAU (0.47) | PLAUTAS1R3TAS1R1TAS1R2KLKB1 | |
| SCHEMBL8230030 | 0.83 | PLAU (0.53) | PLAUTAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL8239843 | 0.83 | PLAU (0.70) | PLAUTAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL8238849 | 0.82 | PLAU (0.88) | PLAUKLKB1MEN1NPC1RAB9A | |
| SCHEMBL8235966 | 0.82 | PLAU (0.59) | PLAUTAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL8237387 | 0.82 | PLAU (0.69) | PLAUTAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL8237186 | 0.81 | PLAU (0.67) | PLAUTAS1R3TAS1R1TAS1R2MEN1 | |
| SCHEMBL8235965 | 0.80 | PLAU (0.54) | PLAU | |
| SCHEMBL8235964 | 0.80 | PLAU (0.85) | PLAUTAS1R3TAS1R1TAS1R2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007072041-A1 | THERAPEUTIC COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |