Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.54 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL90289 | 0.92 | REN (0.65) | RENKCNH2 | |
| SCHEMBL90716 | 0.88 | REN (0.55) | RENKCNH2 | |
| SCHEMBL90282 | 0.86 | REN (0.64) | RENKCNH2 | |
| SCHEMBL89927 | 0.86 | REN (0.75) | RENKCNH2 | |
| SCHEMBL8235958 | 0.86 | REN (0.72) | RENKCNH2 | |
| SCHEMBL89881 | 0.85 | REN (0.44) | RENKCNH2USP30DPP4 | |
| SCHEMBL90725 | 0.83 | REN (0.42) | RENKCNH2USP30DPP4 | |
| SCHEMBL89546 | 0.83 | REN (0.42) | RENKCNH2DPP4 | |
| SCHEMBL90178 | 0.82 | REN (0.41) | RENKCNH2USP30DPP4 | |
| SCHEMBL89844 | 0.82 | REN (0.55) | RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |